2-Dimethylaminopyridine → HCID 178489138, compound

HRID 1295034Notes

Reaction equation

HRID 1295034 reaction equation
[Cl:1][C:2]1[C:3](F)=[C:4]([C:8]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[C:12]([Cl:18])[CH:11]=2)=O)[CH:5]=[CH:6][CH:7]=1.O.[NH2:21][NH2:22].CN(C1C=CC=CN=1)C>N1C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]2[C:3]=1[NH:22][N:21]=[C:8]2[C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[C:12]([Cl:18])[CH:11]=1

Participants

5

Reactant 3

HCID 218852-DimethylaminopyridineHCID 24654Hydrazine hydrate (1:1)HCID 68884772HCID 68884772, compound

Product 1

HCID 178489138HCID 178489138, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Prepared according to Method D, Step A from (3-chloro-2-fluorophenyl)(3-chloro-4-methoxyphenyl)methanone (2.04 g, 6.82 mmol), hydrazine hydrate (2.5 mL), dimethylaminopyridine (0.97 g) and pyridine (12.5 mL). The title compound was obtained as a white solid and recrystallized from ethyl acetate/hexane (1.74 g, 5.94 mmol, 87%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-f08b63ad840f437ba7b5d3d89c456dcd
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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