反应详情

To a solution of ethyl 3-benzyloxy-1-phenyl-1H-pyrazole-4-carboxylate (8.06 g) in tetrahydrofuran (100 ml) was added aluminum lithium hydride (0.95 g) at 0° C. and the mixture was stirred at room temperature for 1 hr. Sodium sulfate 10 hydrate (8.06 g) was added to the reaction mixture and the mixture was stirred at room temperature for 1 hr. The precipitate was filtered off and the filtrate was concentrated. The residue was subjected to silica gel column chromatography, and (3-benzyloxy-1-phenyl-1H-pyrazol-4-yl)methanol (5.91 g, yield 84%) was obtained as colorless crystals from a fraction eluted with ethyl acetate. The crystals were recrystallized from ethyl acetate-hexane. melting point: 93–94° C.

1. stirringthe mixture was stirred at room temperature for 1 hr
2. filtrationThe precipitate was filtered off
3. concentrationthe filtrate was concentrated