反应详情

To a solution of methyl 3-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxybenzyloxy]-1-phenyl-1H-pyrazole-5-carboxylate (12.10 g) in tetrahydrofuran (300 ml) was added aluminum lithium hydride (890 mg) at 0° C. and the mixture was stirred at room temperature for 1 hr. Sodium sulfate 10 hydrate (7.57 g) was added to the reaction mixture and stirred at room temperature for 1 hr. The precipitate was filtered off and the filtrate was concentrated. The obtained colorless crystals were collected by filtration to give [3-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxybenzyloxy]-1-phenyl-1H-pyrazol-5-yl]methanol (11.19 g, yield 98%), which was then recrystallized from ethyl acetate-hexane. melting point: 106–107° C.

1. stirringstirred at room temperature for 1 hr
2. filtrationThe precipitate was filtered off
3. concentrationthe filtrate was concentrated
4. filtrationThe obtained colorless crystals were collected by filtration