1-[3-(6,8-Dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-3-(2-hydroxy-1-hydroxymethylethyl)urea → 1-[3-(6,8-Dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-3-(2-hydroxy-1-hydroxymethylethyl)urea hydrochloride

HRID 1295433Notes

Reaction equation

HRID 1295433 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([Cl:12])[CH:11]=1)[CH2:8][N:7]([CH3:13])[CH2:6][CH:5]2[C:14]1[CH:15]=[C:16]([NH:20][C:21]([NH:23][CH:24]([CH2:27][OH:28])[CH2:25][OH:26])=[O:22])[CH:17]=[CH:18][CH:19]=1>Cl>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([Cl:12])[CH:11]=1)[CH2:8][N:7]([CH3:13])[CH2:6][CH:5]2[C:14]1[CH:15]=[C:16]([NH:20][C:21]([NH:23][CH:24]([CH2:27][OH:28])[CH2:25][OH:26])=[O:22])[CH:17]=[CH:18][CH:19]=1

Participants

3

Reactant 1

HCID 113847081-[3-(6,8-Dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-3-(2-hydroxy-1-hydroxymethylethyl)urea2×

Product 1

HCID 695119091-[3-(6,8-Dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-3-(2-hydroxy-1-hydroxymethylethyl)urea hydrochlorideYield 178.6%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

200 mg of 1-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-3-(2-hydroxy-1-hydroxymethylethyl)urea (Example compound 6) were dissolved in 40 ml of 0.1 M HCl, filtered and freeze-dried to obtain 194 mg of the desired hydrochloride.

Workup

  1. filtrationfiltered
  2. customfreeze-dried

Sources & evidence

ORD record
ord-3bd28a78fa1946c9abcc9023f79cc323
Source dataset
uspto-grants-2007_07
Patent number
US07241775B2

Reaction notes

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