反应详情

9.6 g (39.3 mmol) of 2-hydroxy-1,3-diphenoxypropane are dissolved in 80 ml of tetrahydrofurane (THF) and cooled by an ice bath. To the solution are added dropwise 6.8 g (86.4 mmol) of acetyl chloride and 6.0 g (59.0 mmol) of triethylamine successively. The reaction mixture is stirred at room temperature overnight, poured into 50 ml of water, and extracted with ethyl acetate. The organic phase is washed with water and brine, dried over MgSO4, and concentrated. The residue is purified by flash chromatography on silica gel with ethyl acetate and hexane (1:9) as eluent, yielding 5.1 g of 2-acetyloxy-1,3-diphenoxypropane as a colorless liquid.

1. temperaturecooled by an ice bath
2. extractionextracted with ethyl acetate
3. washThe organic phase is washed with water and brine
4. dry with materialdried over MgSO4
5. concentrationconcentrated
6. customThe residue is purified by flash chromatography on silica gel with ethyl acetate and hexane (1:9) as eluent