反应详情

A solution of 4-(4-methoxybenzoyl)piperidine hydrochloride (3.0 g, 11.7 mmol), in 48% HBr (aq) (16 mL), and acetic acid (16 mL) was heated at reflux for 48 h. The reaction mixture was evaporated to dryness in vacuo to give an off-white solid which was suspended in saturated NaHCO3 (aq). The resulting precipitate was collected by filtration, washed with water, and dried to give the title compound (1.76 g, 73%) as an off-white solid.

1. temperatureat reflux for 48 h
2. customThe reaction mixture was evaporated to dryness in vacuo
3. customto give an off-white solid which
4. filtrationThe resulting precipitate was collected by filtration
5. washwashed with water
6. customdried