反应详情

A mixture of diethyl (3-nitrobenzyl)phosphonate (8.4 g, 0.031 mol) and tert-butyl 4-oxopiperidine-1-carboxylate (6.12 g, 0.031 mol) in dry tetrahydrofuran (120 mL) was treated with a 60% suspension of sodium hydride in oil (1.36 g, 0.034 mmol). The resulting mixture was stirred at room temperature for 4 h, then partitioned between dichloromethane (500 mL) and water (500 mL). The organic extract was dried (Na2SO4) and evaporated in vacuo to give the title compound (9.86 g, 100%) as a solid.

1. custompartitioned between dichloromethane (500 mL) and water (500 mL)
2. extractionThe organic extract
3. dry with materialwas dried (Na2SO4)
4. customevaporated in vacuo