Hydrochloric Acid → HCID 23105929, compound

HRID 1295598Notes

Reaction equation

HRID 1295598 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([NH:12]C=O)([CH3:11])[CH3:10])=[CH:4][C:3]=1[C:15]([F:18])([F:17])[F:16].Cl.C(=O)([O-])[O-].[K+].[K+]>O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([NH2:12])([CH3:10])[CH3:11])=[CH:4][C:3]=1[C:15]([F:16])([F:17])[F:18]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 86071200HCID 86071200, compound

Product 1

HCID 23105929HCID 23105929, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

3.30 g (12.5 mmol) N-[2-(4-fluoro-3-trifluoromethyl-phenyl)-1,1-dimethyl-ethyl]-formamide are combined with 25 mL water and 25 mL conc. hydrochloric acid and refluxed for 2 hours. The reaction mixture is diluted with water, made alkaline with potassium carbonate solution and extracted with dichloromethane. The combined organic phases are dried with sodium sulphate and freed from solvent. Brown oil.

Workup

  1. temperaturerefluxed for 2 hours
  2. extractionextracted with dichloromethane
  3. dry with materialThe combined organic phases are dried with sodium sulphate

Sources & evidence

ORD record
ord-99036bfeb5374e259b7fbebfb6293ad3
Source dataset
uspto-grants-2007_07
Patent number
US07244728B2

Reaction notes

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