Water → HCID 23105928, compound

HRID 1295605Notes

Reaction equation

HRID 1295605 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8](O)[CH:9]([CH3:11])[CH3:10])=[CH:4][C:3]=1[C:13]([F:16])([F:15])[F:14].O.C1(C)C=CC(S(O)(=O)=O)=CC=1.O>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[C:9]([CH3:11])[CH3:10])=[CH:4][C:3]=1[C:13]([F:14])([F:15])[F:16]

Participants

5

Reactant 3

HCID 962WaterHCID 521998p-Toluenesulfonic acid monohydrateHCID 23105941HCID 23105941, compound

Product 1

HCID 23105928HCID 23105928, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

1.50 g (5.9 mmol) 1-(4-chloro-3-trifluoromethyl-phenyl)-2-methyl-propan-1-ol and 0.50 g (2.6 mmol) p-toluenesulphonic acid monohydrate in 50 mL toluene are refluxed for 3 hours using the water separator. After working up analogously to Example 1b) a brown oil is obtained. Yield: 1.4 g; mass spectrometry: [M]+=234/6.

Workup

  1. customis obtained

Sources & evidence

ORD record
ord-6658f3f077a344018e7a0c852cfe038c
Source dataset
uspto-grants-2007_07
Patent number
US07244728B2

Reaction notes

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