Hydrogen Peroxide → HCID 69508634, compound

HRID 1295738Notes

Reaction equation

HRID 1295738 reaction equation
[CH3:1][NH:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([O:10][CH2:11][S:12][CH3:13])[CH:5]=1.[OH:14]O>C(O)(=O)C.C(Cl)Cl.C([O-])([O-])=O.[K+].[K+]>[CH3:13][S:12]([CH2:11][O:10][C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=1)[CH2:3][NH:2][CH3:1])=[O:14]

Participants

6

Reactant 2

HCID 784Hydrogen PeroxideHCID 69507792HCID 69507792, compound

Product 1

HCID 69508634HCID 69508634, compound

Reagents, catalysts & solvents 3

HCID 176Acetic AcidSolventHCID 6344DichloromethaneSolventHCID 11430Potassium CarbonateSolvent

Conditions

Temperature
0 °C

Procedure

Compound from step 3 (592 mg, 3.00 mmol) was dissolved in glacial acetic acid (4 mL) and cooled to 0° C. H2O2 (0.34 mL, 3.00 mmol) was added drop-wise. The mixture was allowed to stir for 6 h. The mixture was then diluted with CH2Cl2 and neutralized with K2CO3. The solids were filtered off. The filtrate was dried over Na2SO4 and concentrated in vacuo to give 640 mg (quant) of a yellow crystalline solid.

Workup

  1. filtrationThe solids were filtered off
  2. dry with materialThe filtrate was dried over Na2SO4
  3. concentrationconcentrated in vacuo
  4. customto give 640 mg (quant) of a yellow crystalline solid

Sources & evidence

ORD record
ord-b63a465c593a4d1fa77a5b9350631b67
Source dataset
uspto-grants-2007_07
Patent number
US07244738B2

Reaction notes

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