Hydrochloric Acid → HCID 21843735, compound

HRID 129583Notes

Reaction equation

HRID 129583 reaction equation
[ClH:1].[CH:2]1([CH2:8][NH:9][CH2:10][CH:11]2[CH2:20][CH2:19][C:18]3[C:13](=[C:14]([O:21][CH3:22])[CH:15]=[CH:16][CH:17]=3)[O:12]2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1>C(OCC)C>[ClH:1].[CH:2]1([CH2:8][NH:9][CH2:10][CH:11]2[CH2:20][CH2:19][C:18]3[C:13](=[C:14]([O:21][CH3:22])[CH:15]=[CH:16][CH:17]=3)[O:12]2)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21843736HCID 21843736, compound

Product 1

HCID 21843735HCID 21843735, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

9.3 ml of a 2.7M hydrogen chloride solution in diethyl ether are added to 7.2 g (15 mmol) of N-cyclohexylmethyl-2-aminomethyl-8-methoxychroman in 200 ml of diethyl ether at 0° to -10° C., while stirring. After 2 hours, the precipitate is filtered off, washed thoroughly with diethyl ether and dried at 60° C./0.01 mbar.

Workup

  1. filtrationthe precipitate is filtered off
  2. washwashed thoroughly with diethyl ether
  3. customdried at 60° C./0.01 mbar

Sources & evidence

ORD record
ord-92d1ee5b3bed48b782aa34cb71fddabd
Source dataset
uspto-grants-1995_11
Patent number
US05468882

Reaction notes

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