反应详情

温度

50 °C

After dissolving N1-methyl-4-(azidomethyl)-5-cyano-2-ethoxybenzamide (931 mg) in tetrahydrofuran (10 ml), 28% aqueous ammonia (2 ml) and triethylphosphine (0.4 ml) were added in that order. The mixture was stirred at 50° C. for 15 minutes. The precipitated crystals were filtered off, washed with tetrahydrofuran, water and ethyl acetate in that order and dried to yield the title compound (365 mg).

1. additionwere added in that order
2. filtrationThe precipitated crystals were filtered off
3. washwashed with tetrahydrofuran, water and ethyl acetate in that order
4. customdried