Hydrochloric Acid → 2-(3-Bromophenyl)propan-2-amine hydrochloride

HRID 1296122Notes

Reaction equation

HRID 1296122 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:8]([NH2:11])([CH3:10])[CH3:9])[CH:5]=[CH:6][CH:7]=1.[ClH:12]>CCOCC.C(O)C.C(OCC)(=O)C>[ClH:12].[Br:1][C:2]1[CH:3]=[C:4]([C:8]([NH2:11])([CH3:9])[CH3:10])[CH:5]=[CH:6][CH:7]=1

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 130256661-(3-Bromophenyl)-1-methylethylamine

Product 1

HCID 532565432-(3-Bromophenyl)propan-2-amine hydrochloride

Reagents, catalysts & solvents 3

HCID 702EthanolSolventHCID 3283Diethyl EtherSolventHCID 8857Ethyl AcetateSolvent

Procedure

To 2-(3-bromophenyl)-2-propylamine 29 in ether is added ethereal HCl. Solvent removal affords a tan solid, which is dissolved in a small volume of ethanol and diluted with ethyl acetate. The tan crystals which form are filtered to afford 2-(3-bromophenyl)-2-propylamine hydrochloride: 1H NMR (CDCl3+CD3OD drop) δ 7.65 (n m, 1H), 7.51 (app t, 2H), 7.32 (m, 1H), 1.77 (s, 6H); MS (CI) m/z 214.0 (MH+)

Workup

  1. customSolvent removal
  2. customaffords a tan solid, which
  3. filtrationThe tan crystals which form are filtered

Sources & evidence

ORD record
ord-076288948783487aab0e7d9416b220a2
Source dataset
uspto-grants-2007_07
Patent number
US07244725B2

Reaction notes

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