Hydrochloric Acid → HCID 11737031, compound

HRID 1296237Notes

Reaction equation

HRID 1296237 reaction equation
C(OC([N:8]1[CH2:22][CH2:21][N:11]2[C:12](=[O:20])[C:13]3[C:18]([CH:10]2[CH2:9]1)=[CH:17][CH:16]=[CH:15][C:14]=3[Cl:19])=O)(C)(C)C.Cl>>[ClH:19].[Cl:19][C:14]1[CH:15]=[CH:16][CH:17]=[C:18]2[C:13]=1[C:12](=[O:20])[N:11]1[CH2:21][CH2:22][NH:8][CH2:9][CH:10]12

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 16115785HCID 16115785, compound

Product 1

HCID 11737031HCID 11737031, compoundYield 185.2%

Procedure

To (±)-N-(t-butoxycarbonyl)-1,3,4,10b-tetrahydro-7-chloropyrazino[2,1-a]isoindol-6(2H)-one (15 mg, 0.05 mmol) was added concentrated hydrochloric acid (1 mL). After 15 min, the resulting solution was concentrated, diluted with water, and lyopholized to give (±)-1,3,4,10b-tetrahydro-7-chloro-pyrazino[2,1-a]isoindol-6(2H)-one hydrochloric acid salt as an off-white solid (12 mg, 100%). MS (ESI) 223.2, 225.2 (M−Cl).

Workup

  1. concentrationthe resulting solution was concentrated
  2. additiondiluted with water

Sources & evidence

ORD record
ord-ddee15f775bf4e168347addeef54547e
Source dataset
uspto-grants-2007_07
Patent number
US07244843B2

Reaction notes

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