反应详情

The solution of ethylmagnesium bromide (3.0 M in ethyl ether, 2.1 mL, 6.3 mmol) in THF (17.0 mL) was cooled to −78° C. To this solution was added the solution of titanium (IV) isopropoxide (0.76 mL, 2.6 mmol) in THF (1.7 mL) dropwise with the temperature below −70° C. After stirred for three minutes, the solution of 4-[(1-benzyl-pyrrolidine-3-carbonyl)-methyl-amino]-piperidine-1-carboxylic acid tert-butyl ester (1.0 g, 2.5 mmol) in THF (1.7 mL) was added. The resulting solution was warmed to room temperature, heated at reflux for one hour and then cooled to 8° C. Ethylmagnesium bromide (3.0M in ethyl ether, 1.8 mL, 5.4 mmol) was added followed by the solution of titanium (IV) isopropoxide (0.66 mL, 2.2 mmol) in THF (1.0 mL) rapidly. The reaction mixture was stirred at room temperature for one hour and partitioned between ethyl acetate and water. The separated organic layer was washed with brine, dried over sodium sulfate and concentrated in vacuo. The residue was purified by preparative thin layer chromatography (60% ethyl acetate in hexane with 0.5% triethylamine) to give pale yellow oil (390 mg, 38%). ESI MS m/z 414.3 (M+H+).

1. temperatureheated
2. temperatureat reflux for one hour
3. temperaturecooled to 8° C
4. stirringThe reaction mixture was stirred at room temperature for one hour
5. custompartitioned between ethyl acetate and water
6. washThe separated organic layer was washed with brine
7. dry with materialdried over sodium sulfate
8. concentrationconcentrated in vacuo
9. customThe residue was purified by preparative thin layer chromatography (60% ethyl acetate in hexane with 0.5% triethylamine)