Sodium hydride → HCID 18186809, compound

HRID 1296609Notes

Reaction equation

HRID 1296609 reaction equation
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([Cl:8])[N:3]=1.[CH3:9][O:10][C:11]1[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=1[CH2:13][OH:14].[H-].[Na+]>>[Cl:8][C:4]1[CH:5]=[N:6][CH:7]=[C:2]([O:14][CH2:13][C:12]2[CH:15]=[CH:16][CH:17]=[CH:18][C:11]=2[O:10][CH3:9])[N:3]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 691542-Methoxybenzyl alcoholHCID 785042,6-Dichloropyrazine

Product 1

HCID 18186809HCID 18186809, compound

Procedure

The title compound was prepared according to the procedure of example 4, step 1 starting from 2,6-dichloropyrazine (298 mg, 2.00 mmol), 2-methoxybenzyl alcohol (303 mg, 2.20 mmol) and NaH (55% in mineral oil, 96 mg, 2.2 mmol). The yield of the crude product was 0.49 g (98%) and was used directly as such in the next step. MS m/z 250 (M)+. HRMS m/z calcd for C12H11ClN2O2 (M)+ 250.0509, found 250.0522.

Sources & evidence

ORD record
ord-bf9630676a7a40039d1e79a4ce5f6e3a
Source dataset
uspto-grants-2007_07
Patent number
US07247633B2

Reaction notes

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