Piperazine → HCID 18186824, compound

HRID 1296655Notes

Reaction equation

HRID 1296655 reaction equation
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][O:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:3]=1.O(CCCCCO)C1C=CC=CC=1.[NH:34]1[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]1.C([O-])([O-])=O.[K+].[K+]>>[O:14]([CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][O:8][C:4]1[CH:5]=[N:6][CH:7]=[C:2]([N:34]2[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]2)[N:3]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

5

Reactant 4

HCID 4837PiperazineHCID 11430Potassium CarbonateHCID 12293201HCID 12293201, compoundHCID 18186774HCID 18186774, compound

Product 1

HCID 18186824HCID 18186824, compound

Procedure

The title compound was prepared according to the procedure of example 50, step 2, starting from 2-chloro-6-[(5-phenoxypentyl)oxy]pyrazine (2.06 g, 7.03 mmol; obtained according to the procedure of example 50, step 1, starting from 5-phenoxy-1-pentanol*), piperazine (1.88 g, 21.8 mmol) and K2CO3 (0.97 g, 7.03 mmol). The yield of the title compound was 1.15 g (48%) which was obtained as a white solid. Purity 100% (HPLC). MS m/z 343 (M+H)+. HRMS m/z calcd for C19H26N4O2 (M)+ 342.2056, found 342.2054. *Described in. J. Org. Chem. 1968, 33, 2271-2284.

Workup

  1. customThe title compound was prepared
  2. customobtained
  3. customwas obtained as a white solid

Sources & evidence

ORD record
ord-0c20a686a4e340488d8cd98685532f1b
Source dataset
uspto-grants-2007_07
Patent number
US07247633B2

Reaction notes

Loading…