Piperazine → HCID 18186926, compound

HRID 1296657Notes

Reaction equation

HRID 1296657 reaction equation
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[N:3]=1.C(C1C=CC=CC=1CO)CC1C=CC=CC=1.[NH:40]1[CH2:45][CH2:44][NH:43][CH2:42][CH2:41]1.C([O-])([O-])=O.[K+].[K+]>>[C:18]1([CH2:17][CH2:16][C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[CH2:9][O:8][C:4]2[CH:5]=[N:6][CH:7]=[C:2]([N:40]3[CH2:45][CH2:44][NH:43][CH2:42][CH2:41]3)[N:3]=2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

5

Reactant 4

HCID 4837PiperazineHCID 11430Potassium CarbonateHCID 70040o-Phenethylbenzyl alcoholHCID 18186871HCID 18186871, compound

Product 1

HCID 18186926HCID 18186926, compound

Procedure

The title compound was prepared according to the procedure of example 50, step 2, starting from 2-chloro-6-{[2-(2-phenylethyl)benzyl]oxy}pyrazine (1.72 g, 5.30 mmol; obtained according to the procedure of example 50, step 1, starting from 2-phenethylbenzyl alcohol), piperazine (1.37 g, 16.0 mmol) and K2CO3 (0.73 g, 5.3 mmol). The yield of the title compound was 1.38 g (69%) which was obtained as an oil. Purity 100% (HPLC). MS m/z 375 (M+H)+. HRMS m/z calcd for C23H26N4O (M)+ 374.2107, found 374.2113.

Workup

  1. customThe title compound was prepared
  2. customobtained
  3. customwas obtained as an oil

Sources & evidence

ORD record
ord-0e22a622d0b24a12a1cfdc882718d91e
Source dataset
uspto-grants-2007_07
Patent number
US07247633B2

Reaction notes

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