Piperazine → HCID 18186782, compound

HRID 1296660Notes

Reaction equation

HRID 1296660 reaction equation
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([O:8][CH2:9][C:10]2[S:11][CH:12]=[CH:13][C:14]=2[N:15]2[CH:19]=[CH:18][CH:17]=[CH:16]2)[N:3]=1.[NH:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1.C([O-])([O-])=O.[K+].[K+]>>[N:20]1([C:2]2[CH:7]=[N:6][CH:5]=[C:4]([O:8][CH2:9][C:10]3[S:11][CH:12]=[CH:13][C:14]=3[N:15]3[CH:19]=[CH:18][CH:17]=[CH:16]3)[N:3]=2)[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1

Participants

4

Reactant 3

HCID 4837PiperazineHCID 11430Potassium CarbonateHCID 18186804HCID 18186804, compound

Product 1

HCID 18186782HCID 18186782, compound

Procedure

The title compound was prepared according to the procedure of example 50, step 2, starting from the product obtained in step 1 above (1.78 g, 6.10 mmol), piperazine (1.58 g, 18.3 mmol) and K2CO3 (0.86 g, 6.2 mmol). The yield of the title compound was 1.43 g (69%) and was obtained as a beige solid. HRMS m/z calcd for C17H19N5OS (M)+ 341.1310, found 341.1301.

Workup

  1. customThe title compound was prepared
  2. customwas obtained as a beige solid

Sources & evidence

ORD record
ord-a6f0fa90325a4ef7a3cb2fe9ef9fb621
Source dataset
uspto-grants-2007_07
Patent number
US07247633B2

Reaction notes

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