Piperazine → 2-{[3-(Benzyloxy)Benzyl]Oxy}-6-(1-Piperazinyl)Pyrazine

HRID 1296662Notes

Reaction equation

HRID 1296662 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:21]=[CH:22][CH:23]=1)[CH2:12][O:13][C:14]1[CH:19]=[N:18][CH:17]=[C:16](Cl)[N:15]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1.C([O-])([O-])=O.[K+].[K+]>>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:21]=[CH:22][CH:23]=1)[CH2:12][O:13][C:14]1[CH:19]=[N:18][CH:17]=[C:16]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[N:15]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 4837PiperazineHCID 11430Potassium CarbonateHCID 181869282-{[3-(Benzyloxy)Benzyl]Oxy}-6-Chloropyrazine

Product 1

HCID 181867902-{[3-(Benzyloxy)Benzyl]Oxy}-6-(1-Piperazinyl)Pyrazine

Procedure

The title compound was prepared according to the procedure of example 50, step 2, starting from the product obtained in step 1 above (1.62 g, 4.96 mmol), piperazine (1.28 g, 14.9 mmol) and K2CO3 (0.70 g, 5.1 mmol). The yield of the title compound was 1.16 g (62%) and was obtained as an oil. HRMS m/z calcd for C22H24N4O2 (M)+ 376.1899, found 376.1890. Anal. (C22H24N4O2) C, H, N.

Workup

  1. customThe title compound was prepared
  2. customwas obtained as an oil

Sources & evidence

ORD record
ord-54ba960d188742cebdfb7170de14b5b4
Source dataset
uspto-grants-2007_07
Patent number
US07247633B2

Reaction notes

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