Methyl iodide → HCID 86595901, compound

HRID 1296740Notes

Reaction equation

HRID 1296740 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:29]=[C:30]([O:33][CH3:34])[C:31]=1[CH3:32])[C:6]([NH:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[N:20]=[C:19]([CH3:21])[O:18][N:17]=2)=[CH:12][C:11]=1[NH:22][C:23](=[O:28])[C:24]([F:27])([F:26])[F:25])=[O:7].CI.[C:37](=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:29]=[C:30]([O:33][CH3:34])[C:31]=1[CH3:32])[C:6]([NH:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[N:20]=[C:19]([CH3:21])[O:18][N:17]=2)=[CH:12][C:11]=1[N:22]([CH3:37])[C:23](=[O:28])[C:24]([F:26])([F:25])[F:27])=[O:7]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 86595900HCID 86595900, compound

Product 1

HCID 86595901HCID 86595901, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
50 °C

Procedure

A suspension of compound 1h (1.1 g, 2.3 mmol), methyl iodide (0.72 mL, 11.5 mmol) and potassium carbonate (1.6 g, 11.5 mmol) in acetone (14 mL) was sealed in a pressure tube and heated at 50° C. for 3 h. The reaction mixture was cooled to rt, filtered, and concentrated on a rotary evaporator to give compound 1i (1.1 g, 100%) as a light yellow solid. ESI-MS m/e 493.1 (M+1).

Workup

  1. customwas sealed in a pressure tube
  2. temperatureThe reaction mixture was cooled to rt
  3. filtrationfiltered
  4. concentrationconcentrated on a rotary evaporator

Sources & evidence

ORD record
ord-072a72201a4946ae82de2f3e62d45b5a
Source dataset
uspto-grants-2007_07
Patent number
US07247654B2

Reaction notes

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