Potassium Carbonate → HCID 69491456, compound

HRID 1296741Notes

Reaction equation

HRID 1296741 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:30]=[C:31]([O:34][CH3:35])[C:32]=1[CH3:33])[C:6]([NH:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[N:20]=[C:19]([CH3:21])[O:18][N:17]=2)=[CH:12][C:11]=1[N:22](C)[C:23](=O)C(F)(F)F)=[O:7].C(=O)([O-])[O-].[K+].[K+]>CO.O>[CH3:35][O:34][C:31]1[CH:30]=[C:5]([CH:4]=[C:3]([O:2][CH3:1])[C:32]=1[CH3:33])[C:6]([NH:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[N:20]=[C:19]([CH3:21])[O:18][N:17]=2)=[CH:12][C:11]=1[NH:22][CH3:23])=[O:7]

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 86595901HCID 86595901, compound

Product 1

HCID 69491456HCID 69491456, compoundYield 34.4%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A suspension of compound 1i (0.11 g, 0.22 mmol) and potassium carbonate (92.5 mg, 0.67 mmol) in a mixture of methanol (2.5 mL) and water (0.4 mL) was stirred at rt for 3 h. The reaction mixture was filtered and concentrated on a rotary evaporator. The residue was dissolved in ethyl acetate and washed with water and brine, dried MgSO4, and concentrated to give compound 1j (30 mg, 34%). ESI-MS m/e 397.3 (M+1).

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationconcentrated on a rotary evaporator
  3. dissolutionThe residue was dissolved in ethyl acetate
  4. washwashed with water and brine, dried MgSO4
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-9b25b8b4d80e4dfb83b6faee3f733784
Source dataset
uspto-grants-2007_07
Patent number
US07247654B2

Reaction notes

Loading…