Diisopropylethylamine → HCID 69456945, compound

HRID 1296781Notes

Reaction equation

HRID 1296781 reaction equation
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH:3]([C:9]([Cl:11])=[O:10])[CH2:2]2.C([N:15](CC)[CH:16]([CH3:18])[CH3:17])(C)C.N[C:22]1C=CC=[C:27]2[C:23]=1[CH:24]=[N:25][NH:26]2>CN(C1C=CN=CC=1)C>[ClH:11].[NH:26]1[CH:27]2[CH:23]([CH:22]=[CH:18][C:16]([NH:15][C:9]([CH:3]3[CH:4]4[CH2:7][CH2:8][N:1]([CH2:6][CH2:5]4)[CH2:2]3)=[O:10])=[CH:17]2)[CH:24]=[N:25]1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 413085NoName_3327HCID 114466161-Azabicyclo[2.2.2]octane-3-carbonyl chloride

Product 1

HCID 69456945HCID 69456945, compound

Reagents, catalysts & solvents 1

HCID 142844-(Dimethylamino)pyridineCatalyst

Procedure

In analogy to the method described in Example 2, 250 mg (2.57 mmol) of 3-quinuclidinecarbonyl chloride, 461 mg (3.57 mmol) of N,N-diisopropylethylamine, catalytic amounts of DMAP (approx. 1 mg) and 158 mg (1.19 mmol) of 4-aminoindazole are reacted.

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-a252e97936ec4030ac78cdd51ff9a925
Source dataset
uspto-grants-2007_07
Patent number
US07247728B2

Reaction notes

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