Hydrochloric Acid → Methylphenidate

HRID 1296784Notes

Reaction equation

HRID 1296784 reaction equation
[C:1]1([CH:7]2[C:14](=[O:15])[N:13]3[CH:8]2[CH2:9][CH2:10][CH2:11][CH2:12]3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[CH3:17][OH:18]>>[CH3:17][O:18][C:14]([CH:7]([CH:8]1[NH:13][CH2:12][CH2:11][CH2:10][CH2:9]1)[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)=[O:15]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 123162767-Phenyl-1-azabicyclo[4.2.0]octan-8-one

Product 1

HCID 4158Methylphenidate

Procedure

reacting the 7-phenyl-1-azabicyclo[4.2.0]octan-8-one obtained in step (i) with a solution of hydrogen chloride in methanol to give methylphenidate;

Sources & evidence

ORD record
ord-2f0f3a8f218e46aab45dc7f746ff7ee8
Source dataset
uspto-grants-2007_07
Patent number
US07247730B2

Reaction notes

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