Diisopropylethylamine → HCID 178518194, compound

HRID 1296806Notes

Reaction equation

HRID 1296806 reaction equation
CS[C:3]1[S:4][C:5](=[CH:9][C:10]2[C:18]3[C:13](=[N:14][CH:15]=[CH:16][CH:17]=3)[NH:12][CH:11]=2)[C:6](=[O:8])[N:7]=1.[F:19][C:20]1[CH:25]=[CH:24][C:23]([C@@H:26]([NH2:29])[CH2:27][OH:28])=[CH:22][CH:21]=1.CCN(C(C)C)C(C)C>>[F:19][C:20]1[CH:21]=[CH:22][C:23]([C@@H:26]([NH:29][C:3]2[S:4]/[C:5](=[CH:9]\[C:10]3[C:18]4[C:13](=[N:14][CH:15]=[CH:16][CH:17]=4)[NH:12][CH:11]=3)/[C:6](=[O:8])[N:7]=2)[CH2:27][OH:28])=[CH:24][CH:25]=1

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 10583003(R)-2-Amino-2-(4-fluorophenyl)ethanolHCID 178503545HCID 178503545, compound

Product 1

HCID 178518194HCID 178518194, compound

Procedure

Then similar procedure as described in example 14b was used, starting from 2-methylsulfanyl-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylene)-thiazol-4-one (example 14a), 2-[(R)-1-(4-fluoro-phenyl)-2-hydroxy-ethylamine and DIEA to give 2-[(R)-1-(4-fluoro-phenyl)-2-hydroxy-ethylamino]-5-[1-(1H-pyrrolo[2,3-b]pyridin-3-yl)-meth-(Z)-ylidene]-thiazol-4-one. LC-MS m/e 383 (MH+).

Sources & evidence

ORD record
ord-591383c500d14f9f996d2f55e20a7364
Source dataset
uspto-grants-2007_07
Patent number
US07247727B2

Reaction notes

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