Acetic Anhydride → 3-(2-Bromo-phenyl)-6-chloro-7-hydroxy-2-methyl-chromen-4-one

HRID 1296869Notes

Reaction equation

HRID 1296869 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([C:11]1[CH:16]=[C:15]([Cl:17])[C:14]([OH:18])=[CH:13][C:12]=1[OH:19])=[O:10].[C:20](OC(=O)C)(=O)[CH3:21].C(=O)([O-])[O-].[K+].[K+]>>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:9](=[O:10])[C:11]2[C:12](=[CH:13][C:14]([OH:18])=[C:15]([Cl:17])[CH:16]=2)[O:19][C:20]=1[CH3:21]

Participants

4

Reactant 3

HCID 7918Acetic AnhydrideHCID 11430Potassium CarbonateHCID 589135862-(2-Bromo-phenyl)-1-(5-chloro-2,4-dihydroxy-phenyl)-ethanone

Product 1

HCID 589135013-(2-Bromo-phenyl)-6-chloro-7-hydroxy-2-methyl-chromen-4-one

Procedure

This compounds was synthesised in the same manner as described above. 2-(2-Bromo-phenyl)-1-(5-chloro-2,4-dihydroxy-phenyl)-ethanone (2.0 g, 5.88 mmol), acetic anhydride (2.0 ml), potassium carbonate (2.5 g 18.1 mmol). The white precipitate formed was shown to contain the required compound and was taken directly onto the next stage.

Workup

  1. customThis compounds was synthesised in the same manner
  2. customThe white precipitate formed

Sources & evidence

ORD record
ord-e23d6ceb7ed64c8cae07c048eda1ab52
Source dataset
uspto-grants-2007_07
Patent number
US07247734B2

Reaction notes

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