4-Chlororesorcinol → HCID 58913638, compound

HRID 1296882Notes

Reaction equation

[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([OH:6])=[CH:4][C:3]=1[OH:9].[F:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]2[CH:22]=[CH:21][C:20]([CH2:23][C:24]([OH:26])=O)=[CH:19][CH:18]=2)=[CH:13][CH:12]=1.P(Cl)(Cl)(Cl)(Cl)Cl.[CH3:33]N(C=O)C>>[Cl:1][C:2]1[CH:8]=[C:7]2[C:5](=[CH:4][C:3]=1[OH:9])[O:6][CH:33]=[C:23]([C:20]1[CH:19]=[CH:18][C:17]([C:14]3[CH:13]=[CH:12][C:11]([F:10])=[CH:16][CH:15]=3)=[CH:22][CH:21]=1)[C:24]2=[O:26]

Participants

Reactant 4

HCID 17314-Chlororesorcinol

HCID 6228Dimethylformamide

HCID 24819Phosphorus pentachloride

HCID 1393927(4'-Fluoro[1,1'-biphenyl]-4-yl)acetic acid

Product 1

HCID 58913638HCID 58913638, compound

Procedure

This compounds was synthesised in the same manner as described above. 4-Chlororesorcinol (0.31 g, 2.17 mmol), (4′-fluorobiphenyl-4-yl)-acetic acid (0.5 g, 2.17 mmol), BF3Et2O (5 ml), PCl5 (0.68 g, 3.3 mmol), DMF (8 ml and 5 ml). 6-chloro-3-(4′-fluoro-biphenyl-4-yl)-7-hydroxy-chromen-4-one precipitated out as a white solid (0.45 g, 68.6%).

Workup

customThis compounds was synthesised in the same manner
custom6-chloro-3-(4′-fluoro-biphenyl-4-yl)-7-hydroxy-chromen-4-one precipitated out as a white solid (0.45 g, 68.6%)

Sources & evidence

ORD record: ord-f7d35fe2f1874f0cad65edb6a0e2df68
Source dataset: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07247734B2

Reaction notes

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