Hydrazine hydrate (1:1) → HCID 178515921, compound

HRID 1296896Notes

Reaction equation

HRID 1296896 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17](=O)[C:16]3[C:11](=[CH:12][C:13]([OH:19])=[CH:14][CH:15]=3)[O:10][CH:9]=2)=[CH:4][CH:3]=1.O.[NH2:21][NH2:22]>C(O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17]([C:16]3[CH:15]=[CH:14][C:13]([OH:19])=[CH:12][C:11]=3[OH:10])=[N:21][NH:22][CH:9]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 53983673-(4-bromophenyl)-7-hydroxy-4H-chromen-4-one

Product 1

HCID 178515921HCID 178515921, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

This compounds was synthesised in the same manner as described in the preceding experiment. 3-(4-Bromo-phenyl)-7-hydroxy-chromen-4-one (0.1 g, 0.3 mmol), hydrazine hydrate (4 ml), ethanol (10 ml). The crude solid product was washed in hot ether to give 4-[4-(4-Bromo-phenyl)-1H-pyrazol-3-yl]-benzene-1,3-diol as a white solid (0.069, 60.6%); Rf 0.44 Cf SM 0.79 ethyl acetate/hexane (75/25).

Workup

  1. customThis compounds was synthesised in the same manner
  2. washThe crude solid product was washed in hot ether

Sources & evidence

ORD record
ord-6cea44d539ca4d548c3c6b40f49a33af
Source dataset
uspto-grants-2007_07
Patent number
US07247734B2

Reaction notes

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