Hydrazine hydrate (1:1) → HCID 178489847, compound

HRID 1296908Notes

Reaction equation

HRID 1296908 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[OH:12])[O:8][CH:7]=[C:6]([C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH3:20])[CH:14]=1)[C:5]2=O.O.[NH2:23][NH2:24]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:5]2[C:6]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH3:20])[CH:14]=3)=[CH:7][NH:24][N:23]=2)[C:9]([OH:8])=[CH:10][C:11]=1[OH:12]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 58913623HCID 58913623, compound

Product 1

HCID 178489847HCID 178489847, compoundYield 46%

Procedure

This compounds was synthesised in the same manner as described above. 6-Chloro-7-hydroxy-3-(3-methoxy-phenyl)-chromen-4-on (1.0 g, 3.3 mmol), Hydrazine hydrate (8 ml). The quenched reaction was extracted into ethyl acetate, washed (water), dried (MgSO4), and the solvent removed under vacuum to give 4-Chloro-6-[4-(3-methoxy-phenyl)-1H-pyrazol-3-yl]-benzene-1,3-diol as a white solid (0.48 g, 46%); Rf 0.5 ethyl acetate/hexane (80/20)].

Workup

  1. customThis compounds was synthesised in the same manner
  2. customThe quenched reaction
  3. extractionwas extracted into ethyl acetate
  4. washwashed (water)
  5. dry with materialdried (MgSO4)
  6. customthe solvent removed under vacuum

Sources & evidence

ORD record
ord-6e6a9dd210c540a9a389ab90026ce742
Source dataset
uspto-grants-2007_07
Patent number
US07247734B2

Reaction notes

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