Hydrazine hydrate (1:1) → HCID 178511014, compound

HRID 1296926Notes

Reaction equation

HRID 1296926 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[OH:12])[O:8][CH:7]=[C:6]([C:13]1[CH:14]=[C:15]([CH:23]=[CH:24][CH:25]=1)[O:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]#[N:22])[C:5]2=O.O.[NH2:28][NH2:29]>>[Cl:1][C:2]1[C:11]([OH:12])=[CH:10][C:9]([OH:8])=[C:4]([C:5]2[C:6]([C:13]3[CH:14]=[C:15]([CH:23]=[CH:24][CH:25]=3)[O:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]#[N:22])=[CH:7][NH:29][N:28]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 58913601HCID 58913601, compound

Product 1

HCID 178511014HCID 178511014, compoundYield 87%

Procedure

This compound was synthesised in the same manner as described above. 5-[3-(6-Chloro-7-hydroxy-4-oxo-4H-chromen-3-yl)-phenoxy]-pentanenitrile (0.1 g, 0.27 mmol), Hydrazine hydrate (5 ml). The precipitate formed on quenching was filtered to give 5-{3-[3-(5-Chloro-2,4-dihydroxy-phenyl)-1H-pyrazol-4-yl]-phenoxy}-pentanenitrile as a white solid (0.09 g, 87.0%); Rf 0.6 ethyl acetate/hexane (70/30)].

Workup

  1. customThis compound was synthesised in the same manner
  2. customThe precipitate formed
  3. customon quenching
  4. filtrationwas filtered

Sources & evidence

ORD record
ord-c536cd0af04440308f55737ca0ee6bb8
Source dataset
uspto-grants-2007_07
Patent number
US07247734B2

Reaction notes

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