2-Hydrazinoethanol → HCID 136049264, compound

HRID 1296954Notes

Reaction equation

HRID 1296954 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17](=O)[C:16]3[C:11](=[CH:12][C:13]([OH:20])=[C:14]([Cl:19])[CH:15]=3)[O:10][CH:9]=2)=[CH:4][CH:3]=1.[NH:21]([CH2:23][CH2:24][OH:25])[NH2:22]>C(O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17]([C:16]3[CH:15]=[C:14]([Cl:19])[C:13]([OH:20])=[CH:12][C:11]=3[OH:10])=[N:22][N:21]([CH2:23][CH2:24][OH:25])[CH:9]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 80172-HydrazinoethanolHCID 58913628HCID 58913628, compound

Product 1

HCID 136049264HCID 136049264, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3-(4-Bromo-phenyl)-6-chloro-7-hydroxy-chromen-4-one (0.1 g, 0.28 mmol), and 2-Hydrazino-ethanol (0.04 g) were suspended in ethanol (10 ml) and refluxed for 1 hr. 4-[4-(4-Bromo-phenyl)-1-(2-hydroxy-ethyl)-1H-pyrazol-3-yl]-6-chloro-benzene-1,3-diol precipitated out on quenching as a white solid (0.09 g, 78.8%).

Workup

  1. temperaturerefluxed for 1 hr
  2. custom4-[4-(4-Bromo-phenyl)-1-(2-hydroxy-ethyl)-1H-pyrazol-3-yl]-6-chloro-benzene-1,3-diol precipitated out
  3. customon quenching as a white solid (0.09 g, 78.8%)

Sources & evidence

ORD record
ord-08388c1358994e889113a42429edb6b8
Source dataset
uspto-grants-2007_07
Patent number
US07247734B2

Reaction notes

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