3,3-Diphenylpropanol → (3,3-Diphenylpropane-1-yl)4-chloroacetoacetate

HRID 1297028Notes

Reaction equation

HRID 1297028 reaction equation
[Cl:1][CH2:2][C:3](=[O:10])[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6].[C:11]1([CH:17]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)CCO)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C1(C)C=CC=CC=1>[C:11]1([CH:17]([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH2:9][CH2:8][O:7][C:5](=[O:6])[CH2:4][C:3]([CH2:2][Cl:1])=[O:10])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

4

Reactant 2

HCID 299083,3-DiphenylpropanolHCID 69484Ethyl 4-chloroacetoacetate

Product 1

HCID 86760519(3,3-Diphenylpropane-1-yl)4-chloroacetoacetate

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

3.2 ml (23.7 mmol) of ethyl 4-chloroacetoacetate and 5.00 g (23.6 mmol) of 3,3-diphenyl-1-propanol were heated at 130° C. in 100 ml of toluene overnight. Toluene was distilled out under reduced pressure to obtain the title compound.

Workup

  1. distillationToluene was distilled out under reduced pressure

Sources & evidence

ORD record
ord-e835d43cf5de477aaacabebde4532375
Source dataset
uspto-grants-2007_07
Patent number
US07247645B2

Reaction notes

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