HCID 86586137, compound → HCID 17825645, compound

HRID 1297041Notes

Reaction equation

HRID 1297041 reaction equation
[CH2:1]([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]([C:17]([C:32](=O)[CH3:33])=[CH:18][C:19]2[CH:20]=[C:21]([CH:29]=[CH:30][CH:31]=2)[C:22]([O:24]CCC#N)=[O:23])=[O:16])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:35]1([CH:41]([C:51]2[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=2)[CH2:42][CH2:43][O:44][C:45](=[O:50])/[CH:46]=[C:47](\[NH2:49])/[CH3:48])[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1>CC(O)C>[CH2:1]([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]([C:17]2[CH:18]([C:19]3[CH:31]=[CH:30][CH:29]=[C:21]([C:22]([OH:24])=[O:23])[CH:20]=3)[C:46]([C:45]([O:44][CH2:43][CH2:42][CH:41]([C:51]3[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=3)[C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)=[O:50])=[C:47]([CH3:48])[NH:49][C:32]=2[CH3:33])=[O:16])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 86586137HCID 86586137, compoundHCID 86586138HCID 86586138, compound

Product 1

HCID 17825645HCID 17825645, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

2.05 g (3.99 mmol) of 2-cyanoethyl 3-[2-(4-benzyl-[1,4]diazepane-1-carbonyl)-3-oxobutenyl]benzoate and 1.18 g (3.99 mmol) of (3,3-diphenylpropyl)3-aminocrotonate were stirred in 40 ml of 2-propanol at 80° C. overnight. After the concentration under reduced pressure, the product was purified by the silica gel chromatography (chloroform/methanol=100/1) to obtain the title compound.

Workup

  1. concentrationAfter the concentration under reduced pressure
  2. customthe product was purified by the silica gel chromatography (chloroform/methanol=100/1)

Sources & evidence

ORD record
ord-25a23ae841b04a4e8ab96dd19803cd5a
Source dataset
uspto-grants-2007_07
Patent number
US07247645B2

Reaction notes

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