Triethylamine → 7-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide

HRID 1297064Notes

Reaction equation

HRID 1297064 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[S:10]([NH2:13])(=[O:12])=[O:11].Cl.[CH:15](N)=N.C(N(CC)CC)C>C1(C)C=CC=CC=1>[CH3:9][O:8][C:5]1[CH:6]=[CH:7][C:2]2[NH:1][CH:15]=[N:13][S:10](=[O:11])(=[O:12])[C:3]=2[CH:4]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 10313058Methanimidamide, hydrochloride (1:1)HCID 112526652-Amino-5-methoxybenzenesulfonamide

Product 1

HCID 574238877-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A suspension of 3.0 g of 2-amino-5-methoxy-benzenesulphonamide is stirred for 1 night at 80° C. in the presence of 1.31 g of formamidine hydrochloride and 2.27 ml of triethylamine in 50 ml of toluene. The toluene is evaporated off in vacuo. The residue is taken up in water and the precipitate is filtered off.

Workup

  1. customThe toluene is evaporated off in vacuo
  2. filtrationthe precipitate is filtered off

Sources & evidence

ORD record
ord-f5d30bfff6d74d95a7625a7a8922fcdd
Source dataset
uspto-grants-2007_07
Patent number
US07250411B2

Reaction notes

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