Nitromethane → HCID 11412713, compound

To a solution of cyano-cyclopentylidene-acetic acid methyl ester (20.8 g, 126 mmol), in acetonitrile (500 mL) was added nitromethane (34 mL, 630 mmol, 5 eq) followed by dropwise addition of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) (18.8 mL, 126 mmol). The reaction solution turned orange upon the addition of DBU. The reaction mixture was stirred at room temperature for 16 hours. Another portion of DBU (1 mL) was added and stirred for 1 hour. The reaction mixture was partitioned between ether (1 L) and 1N HCl (400 mL) and the layers separated. The organic layer was washed with 1N HCl (2×300 mL), brine (2×200 mL), dried over sodium sulfate, filtered and evaporated. The residue was chromatographed on a wet-packed silica gel column eluting with 4-6% ethyl acetate/hexanes. The appropriate fractions were combined and evaporated to furnish 14.0 g (62%) of 1-cyano-spiro[2.4]heptane-1-carboxylic acid methyl ester as a clear oil: 1H NMR (300 MHz, CDCl3) δ 1.64 (d, J=5.0 Hz, 1H), 1.70-1.88 (m, 7H), 2.14 (d, J=5.0 Hz, 1H), 2.1-2.19 (m, 1H), 3.82 (s, 3H); MS (APCI) m/z 180 [M+H]+.

1. stirringstirred for 1 hour
2. customThe reaction mixture was partitioned between ether (1 L) and 1N HCl (400 mL)
3. customthe layers separated
4. washThe organic layer was washed with 1N HCl (2×300 mL), brine (2×200 mL)
5. dry with materialdried over sodium sulfate
6. filtrationfiltered
7. customevaporated
8. customThe residue was chromatographed on a wet-packed silica gel column
9. washeluting with 4-6% ethyl acetate/hexanes
10. customevaporated

ORD record

ord-99d67cf863f44d309d410d7d6166aa94

Source dataset

uspto-grants-2007_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07250433B2