Lithium Hydroxide → HCID 11500555, compound

HRID 1297263Notes

Reaction equation

HRID 1297263 reaction equation
C([O:3][C:4]([C:6]1([CH2:20][CH:21]=[CH2:22])[C:10]2[NH:11][C:12]3[C:13]([Cl:19])=[CH:14][CH:15]=[C:16]([Cl:18])[C:17]=3[C:9]=2[CH2:8][CH2:7]1)=[O:5])C.[OH-].[Li+]>C(O)C>[CH2:20]([C:6]1([C:4]([OH:5])=[O:3])[C:10]2[NH:11][C:12]3[C:13]([Cl:19])=[CH:14][CH:15]=[C:16]([Cl:18])[C:17]=3[C:9]=2[CH2:8][CH2:7]1)[CH:21]=[CH2:22]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 69347014HCID 69347014, compound

Product 1

HCID 11500555HCID 11500555, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 3-Allyl-5,8-dichloro-1,2,3,4-tetrahydro-cyclopenta[b]indole-3-carboxylic acid ethyl ester was added 1 mL of 2.0 M lithium hydroxide aqueous solution and 1 mL of ethanol. The reaction mixture was stirred at room temperature for 2 hours than concentrated. The residue was purified by reverse phase HPLC to give the desired product.

Workup

  1. concentrationthan concentrated
  2. customThe residue was purified by reverse phase HPLC

Sources & evidence

ORD record
ord-aa336a1547174ba7b2b96ac9670e5eab
Source dataset
uspto-grants-2007_07
Patent number
US07250441B2

Reaction notes

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