反应详情

温度

90 °C

A mixture of 4-iodoaniline (50 g, 0.23 mol) and diethyl ethoxymethylenemalonate (50.3 g, 0.23 mmol) was stirred at 90° C. for 10 hours. 150 mL of ethanol was added and the mixture was refluxed for 3 h. After cooling, the solid was collected, washed with hexane and dried over the oven to obtain 2-[(4-iodo-phenylamino)-methylene]-malonic acid diethyl ester (81 g, 91%) as a white solid.

1. temperaturethe mixture was refluxed for 3 h
2. temperatureAfter cooling
3. customthe solid was collected
4. washwashed with hexane
5. customdried over the oven