6-Formyl-4-methoxy-3-(5-methyl-oxazol-2-yl)-quinoline → Piperidine

HRID 1297640Notes

Reaction equation

HRID 1297640 reaction equation
[CH:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][C:7]([C:13]1[O:14][C:15]([CH3:18])=[CH:16][N:17]=1)=[C:6]2[O:19][CH3:20])=O.[F:21][C:22]1[CH:23]=[C:24]([CH2:28][CH2:29][NH:30][C:31]2[S:32][CH2:33][C:34](=[O:36])[N:35]=2)[CH:25]=[CH:26][CH:27]=1>>[NH:9]1[CH2:10][CH2:5][CH2:6][CH2:7][CH2:8]1.[F:21][C:22]1[CH:23]=[C:24]([CH2:28][CH2:29][NH:30][C:31]2[S:32]/[C:33](=[CH:1]\[C:3]3[CH:4]=[C:5]4[C:10](=[CH:11][CH:12]=3)[N:9]=[CH:8][C:7]([C:13]3[O:14][C:15]([CH3:18])=[CH:16][N:17]=3)=[C:6]4[O:19][CH3:20])/[C:34](=[O:36])[N:35]=2)[CH:25]=[CH:26][CH:27]=1

Participants

4

Reactant 2

HCID 585858616-Formyl-4-methoxy-3-(5-methyl-oxazol-2-yl)-quinolineHCID 178516943HCID 178516943, compound

Product 2

HCID 8082PiperidineHCID 178486803HCID 178486803, compound

Procedure

Similar procedure as described in example 1g was used, starting from 6-formyl-4-methoxy-3-(5-methyl-oxazol-2-yl)-quinoline (example 16d), 2-[2-(3-fluoro-phenyl)-ethylamino]-thiazol-4-one (example 16e), benzolic and piperidine to give 2-[2-(3-Fluoro-phenyl)-ethylamino]-5-[1-[4-methoxy-3-(5-methyl-oxazol-2-yl)-quinolin-6-yl]-meth-(Z)-ylidene]-thiazol-4-one. LC-MS m/e 489 (MH+).

Sources & evidence

ORD record
ord-1ef368aaf67a4c80a2523cecb7441886
Source dataset
uspto-grants-2007_07
Patent number
US07250515B2

Reaction notes

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