Diisopropylethylamine → HCID 178466952, compound

HRID 1297647Notes

Reaction equation

HRID 1297647 reaction equation
[CH2:1]([O:3][C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11](/[CH:14]=[C:15]3/[C:16](=[O:22])[N:17]=[C:18](SC)[S:19]/3)[CH:12]=2)[N:7]=[CH:6][C:5]=1[C:23]#[N:24])[CH3:2].[F:25][C:26]([F:35])([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][N:30]=1)[CH2:27][NH2:28].CCN(C(C)C)C(C)C>>[F:35][C:26]([F:25])([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][N:30]=1)[CH2:27][NH:28][C:18]1[S:19]/[C:15](=[CH:14]\[C:11]2[CH:12]=[C:13]3[C:8](=[CH:9][CH:10]=2)[N:7]=[CH:6][C:5]([C:23]#[N:24])=[C:4]3[O:3][CH2:1][CH3:2])/[C:16](=[O:22])[N:17]=1

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 99641672,2-Difluoro-2-pyridin-2-ylethaneamineHCID 585858204-Ethoxy-6-[2-methylsulfanyl-4-oxo-4h-thiazol-(5z)-ylidenemethyl]-quinoline-3-carbonitrile

Product 1

HCID 178466952HCID 178466952, compound

Procedure

Similar procedure as described in example 14h was used, starting from 4-ethoxy-6-[2-methylsulfanyl-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-quinoline-3-carbonitrile (example 14g), 2,2-difluoro-2-pyridin-2-yl-ethylamine and DIEA to give 6-[2-(2,2-Difluoro-2-pyridin-2-yl-ethylamino)-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-4-ethoxy-quinoline-3-carbonitrile. LC-MS m/e 466 (MH+).

Sources & evidence

ORD record
ord-dde64e3c5aaf473d9aa342566cd2effc
Source dataset
uspto-grants-2007_07
Patent number
US07250515B2

Reaction notes

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