Sodium hydride → HCID 58585805, compound

HRID 1297653Notes

Reaction equation

HRID 1297653 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([OH:14])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[I:15][C:16]1[CH:17]=[C:18]2[C:23](=[CH:24][CH:25]=1)[N:22]=[CH:21][C:20]([C:26]#[N:27])=[CH:19]2.[H-].[Na+]>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:19]2[C:18]3[C:23](=[CH:24][CH:25]=[C:16]([I:15])[CH:17]=3)[N:22]=[CH:21][C:20]=2[C:26]#[N:27])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylateHCID 68824722HCID 68824722, compound

Product 1

HCID 58585805HCID 58585805, compound

Procedure

Similar procedure as described in example 28a was used, starting from 4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester, 6-iodo-quinoline-3-carbonitrile (example 14c) and sodium hydride to give 4-(3-cyano-6-iodo-quinolin-4-yloxy)-piperidine-1-carboxylic acid tert-butyl ester. LC-MS m/e 480 (MH+).

Sources & evidence

ORD record
ord-065d33a6621945a6b6c5871cef514ce8
Source dataset
uspto-grants-2007_07
Patent number
US07250515B2

Reaction notes

Loading…