Tert-Butylamine → HCID 178466951, compound

HRID 1297656Notes

Reaction equation

HRID 1297656 reaction equation
[CH2:1]([O:3][C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11](/[CH:14]=[C:15]3/[C:16](=[O:22])[N:17]=[C:18](SC)[S:19]/3)[CH:12]=2)[N:7]=[CH:6][C:5]=1[C:23]#[N:24])[CH3:2].[C:25]([NH2:29])([CH3:28])([CH3:27])[CH3:26].CCN(C(C)C)C(C)C>>[C:25]([NH:29][C:18]1[S:19]/[C:15](=[CH:14]\[C:11]2[CH:12]=[C:13]3[C:8](=[CH:9][CH:10]=2)[N:7]=[CH:6][C:5]([C:23]#[N:24])=[C:4]3[O:3][CH2:1][CH3:2])/[C:16](=[O:22])[N:17]=1)([CH3:28])([CH3:27])[CH3:26]

Participants

4

Reactant 3

HCID 6385Tert-ButylamineHCID 81531DiisopropylethylamineHCID 585858204-Ethoxy-6-[2-methylsulfanyl-4-oxo-4h-thiazol-(5z)-ylidenemethyl]-quinoline-3-carbonitrile

Product 1

HCID 178466951HCID 178466951, compound

Procedure

Similar procedure as described in example 14h was used, starting from 4-ethoxy-6-[2-methylsulfanyl-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-quinoline-3-carbonitrile (example 14g), tert-butylamine and DIEA to give 6-[2-tert-Butylamino-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-4-ethoxy-quinoline-3-carbonitrile. LC-MS m/e 381 (MH+).

Sources & evidence

ORD record
ord-9d972a880f9c46b894f33e7039cd8b5d
Source dataset
uspto-grants-2007_07
Patent number
US07250515B2

Reaction notes

Loading…