Methanesulfonic Acid → 6-[2-amino-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-4-isobutyl-quinoline-3-carbonitrile methanesulfonic acid salt

HRID 1297674Notes

Reaction equation

HRID 1297674 reaction equation
[NH2:1][C:2]1[S:3]/[C:4](=[CH:8]\[C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][CH:18]=2)[N:15]=[CH:14][C:13]([C:19]#[N:20])=[C:12]3[CH2:21][CH:22]([CH3:24])[CH3:23])/[C:5](=[O:7])[N:6]=1.[CH3:25][S:26]([OH:29])(=[O:28])=[O:27]>>[CH3:25][S:26]([OH:29])(=[O:28])=[O:27].[NH2:1][C:2]1[S:3]/[C:4](=[CH:8]\[C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][CH:18]=2)[N:15]=[CH:14][C:13]([C:19]#[N:20])=[C:12]3[CH2:21][CH:22]([CH3:24])[CH3:23])/[C:5](=[O:7])[N:6]=1

Participants

3

Reactant 2

HCID 6395Methanesulfonic AcidHCID 116241916-[2-Amino-4-oxo-4h-thiazol-(5z)-ylidenemethyl]-4-isobutyl-quinoline-3-carbonitrile

Product 1

HCID 1317265416-[2-amino-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-4-isobutyl-quinoline-3-carbonitrile methanesulfonic acid salt

Procedure

Similar procedure as described in example 47 was used, starting from 6-[2-amino-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-4-isobutyl-quinoline-3-carbonitrile (example 46g) and methanesulfonic acid to give 6-[2-amino-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-4-isobutyl-quinoline-3-carbonitrile methanesulfonic acid salt. LC-MS m/e 337 (MH+).

Sources & evidence

ORD record
ord-3bb8cd6e6fd242288a9e7ad44821bdde
Source dataset
uspto-grants-2007_07
Patent number
US07250515B2

Reaction notes

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