Hydrochloric Acid → HCID 178458713, compound

HRID 1297694Notes

Reaction equation

HRID 1297694 reaction equation
[NH:1]([C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][C:14]([C:20]#[N:21])=[C:13]3[O:22][CH:23]([CH3:25])[CH3:24])/[C:6](=[O:8])[N:7]=1)[NH2:2].[ClH:26]>C(#N)C.O>[ClH:26].[NH:1]([C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][C:14]([C:20]#[N:21])=[C:13]3[O:22][CH:23]([CH3:25])[CH3:24])/[C:6](=[O:8])[N:7]=1)[NH2:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178458712HCID 178458712, compound

Product 1

HCID 178458713HCID 178458713, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6342AcetonitrileSolvent

Procedure

To the solution of 6-[2-hydrazino-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-4-isopropoxy-quinoline-3-carbonitrile (example 59, 15 mg, 0.042 mmol) in acetonitrile and water (8 mL), hydrochloride acid (1N, 0.17 mL) was added. The reaction completed by stirring the above mixture at room temperature for a short period of time. Then the solvents and excess hydrochloride acid were removed by vacuum and lyophilizer to give 6-[2-hydrazino-4-oxo-4H-thiazol-(5Z)-ylidenemethyl]-4-isopropoxy-quinoline-3-carbonitrile hydrochloride salt. LC-MS m/e 354 (MH+).

Workup

  1. customThen the solvents and excess hydrochloride acid were removed by vacuum and lyophilizer

Sources & evidence

ORD record
ord-c79223a2fabb44d9b7d2ea8700e7a8c3
Source dataset
uspto-grants-2007_07
Patent number
US07250515B2

Reaction notes

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