Hydrazine hydrate (1:1) → 1-(3-Aminopropyl)-4-[bis(4-fluorophenyl)-methylene]piperidine

HRID 129770Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 129770
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:29]2[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=2)=[C:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][N:18]3C(=O)C4=CC=CC=C4C3=O)[CH2:11][CH2:10]2)=[CH:4][CH:3]=1.O.NN>>[NH2:18][CH2:17][CH2:16][CH2:15][N:12]1[CH2:13][CH2:14][C:9](=[C:8]([C:29]2[CH:30]=[CH:31][C:32]([F:35])=[CH:33][CH:34]=2)[C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)[CH2:10][CH2:11]1

Komponenten

3

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 193703024-[Bis(4-fluorophenyl)methylene]-1-(3-phthalimidopropyl)piperidine

Produkt 1

HCID 193703231-(3-Aminopropyl)-4-[bis(4-fluorophenyl)-methylene]piperidineAusbeute 20 %

Versuchsvorschrift

The title compound was prepared in a yield of 20% in a similar manner to that described in Preparation 15' by reacting 4-[bis(4-fluorophenyl)methylene]-1-(3-phthalimidopropyl)piperidine (prepared as described in Preparation 48') and hydrazine hydrate.

Aufarbeitung

  1. customdescribed in Preparation 15'
  2. customprepared

Quellen und Nachweise

ORD-Eintrag
ord-c1f28732367f4279bda2dbba8120ff17
Quelldatensatz
uspto-grants-1995_11
Patentnummer
US05470851

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