3-Pentanol → HCID 58585864, compound

HRID 1297716Notes

Reaction equation

HRID 1297716 reaction equation
[CH3:1][CH2:2][CH:3]([OH:6])[CH2:4][CH3:5].Cl[C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([I:18])[CH:16]=2)[N:11]=[CH:10][C:9]=1[C:19]#[N:20].[H-].[K+]>C1COCC1>[CH2:2]([CH:3]([O:6][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([I:18])[CH:16]=2)[N:11]=[CH:10][C:9]=1[C:19]#[N:20])[CH2:4][CH3:5])[CH3:1]

Participants

5

Reactant 3

HCID 114283-PentanolHCID 82127Potassium hydrideHCID 224667694-Chloro-6-iodoquinoline-3-carbonitrile

Product 1

HCID 58585864HCID 58585864, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Similar procedure as described in example 28a was used, starting from 3-pentanol, 4-chloro-6-iodo-quinoline-3-carbonitrile (example 14c) and potassium hydride in a solvent system of THF to give 4-(1-ethyl-propoxy)-6-iodo-quinoline-3-carbonitrile. LC-MS m/e 367 (MH+).

Sources & evidence

ORD record
ord-0aac626d0f3043e79bf9d35981749f77
Source dataset
uspto-grants-2007_07
Patent number
US07250515B2

Reaction notes

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