Isobutyl mercaptan → HCID 58585811, compound

HRID 1297718Notes

Reaction equation

HRID 1297718 reaction equation
[CH3:1][CH:2]([CH3:5])[CH2:3][SH:4].Cl[C:7]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([I:17])[CH:15]=2)[N:10]=[CH:9][C:8]=1[C:18]#[N:19].[H-].[K+]>O1CCCC1>[I:17][C:14]1[CH:15]=[C:16]2[C:11](=[CH:12][CH:13]=1)[N:10]=[CH:9][C:8]([C:18]#[N:19])=[C:7]2[S:4][CH2:3][CH:2]([CH3:5])[CH3:1]

Participants

5

Reactant 3

HCID 10558Isobutyl mercaptanHCID 82127Potassium hydrideHCID 224667694-Chloro-6-iodoquinoline-3-carbonitrile

Product 1

HCID 58585811HCID 58585811, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Similar procedure as described in example 28a was used, starting from 2-methyl-propane-1-thiol, 4-chloro-6-iodo-quinoline-3-carbonitrile (example 14c) and potassium hydride in a solvent system of tetrahydrofuran to give 6-iodo-4-isobutylsulfanyl-quinoline-3-carbonitrile. LC-MS m/e 369(MH+).

Sources & evidence

ORD record
ord-01d712fe568c4b669c457614e14af249
Source dataset
uspto-grants-2007_07
Patent number
US07250515B2

Reaction notes

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