Methyl iodide → HCID 68825957, compound

HRID 1297737Notes

Reaction equation

HRID 1297737 reaction equation
[CH2:1]([O:3][C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([CH:14]=[C:15]3[S:19][C:18](=[S:20])[NH:17][C:16]3=[O:21])[CH:12]=2)[N:7]=[CH:6][C:5]=1[S:22]([CH3:25])(=[O:24])=[O:23])[CH3:2].IC.[CH:28](N(C(C)C)CC)(C)[CH3:29]>C(#N)C>[CH2:1]([O:3][C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([CH:14]=[C:15]3[S:19][C:18]([S:20][CH2:28][CH3:29])=[N:17][C:16]3=[O:21])[CH:12]=2)[N:7]=[CH:6][C:5]=1[S:22]([CH3:25])(=[O:23])=[O:24])[CH3:2]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 81531DiisopropylethylamineHCID 76823851HCID 76823851, compound

Product 1

HCID 68825957HCID 68825957, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Similar procedure as described in example 41b was used, starting from 5-(4-ethoxy-3-methanesulfonyl-quinolin-6-ylmethylene)-2-thioxo-thiazolidin-4-one (example 74d), iodomethane, and DIEA (diisopropylethylamine) in acetonitrile to give 5-(4-ethoxy-3-methanesulfonyl-quinolin-6-ylmethylene)-2-ethylsulfanyl-thiazol-4-one. LC-MS m/e 409 (MH+).

Sources & evidence

ORD record
ord-16b898fed852429e87cc0dcb02651de0
Source dataset
uspto-grants-2007_07
Patent number
US07250515B2

Reaction notes

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