反应详情

Combine 3,3-Bis-[4-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethyl-phenyl]-1,3-dihydro-indol-2-one (0.580 g, 0.963 mmol), 4-methoxyphenylboronic acid (0.293 g, 1.93 mmol), copper (II) acetate (0.175 g, 0.963 mmol), triethylamine (0.27 mL, 1.93 mmol), 4 angstrom molecular sieves, and dichloromethane (15 mL). Stir at room temperature overnight under ambient atmosphere. Filter the reaction through Celite. Elute through a column of silica gel with 80% dichloromethane in hexanes and concentrate. Dissolve the resulting compound (0.501 g, 0.708 mmol), in THF (5 mL). Add a solution of tetrabutylammonium fluoride (1.0 M) in THF (1.80 mL). Stir for 1 h. Add 1N aqueous HCl(10 mL), water (40 mL), and add ethyl acetate (50 mL). Separate the layers, and concentrate the organic layer in vacuo. Chromatograph on silica gel eluting with ethyl acetate to give 0.285 g (62%) of the title compound: mass spectrum (FAB): m/z=480(M+1); 1H NMR(DMSO-d6): δ8.23 (s, 2H), 7.33-7.29 (m, 3H), 7.21 (td, 1H), 7.11-7.06 (m, 3H), 6.73 (s, 4H), 6.70 (d, 1), 3.70 (s, 3H), 2.07 (s, 12H).

1. filtrationFilter
2. customthe reaction through Celite
3. washElute through a column of silica gel with 80% dichloromethane in hexanes
4. concentrationconcentrate
5. stirringStir for 1 h
6. customSeparate the layers
7. concentrationconcentrate the organic layer in vacuo