反应详情

温度

70 °C

600 ml of toluene, 200 g of cyanoacetamide, 193 g of cyclohexanone, 15 g of ammonium acetate and 24 g of acetic acid are placed in a 2 litre flask equipped with a mechanical stirrer, thermometer and Dean-Stark trap connected to a condenser, under nitrogen flow. The mixture is heated under reflux, simultaneously separating the water by distilling the water-toluene azeotrope. The separated water is collected in the Dean-Stark trap and removed at suitable time intervals. After 2 hours, on completion of the azeotropic distillation, it is cooled to 70° C., washed with 400 ml of a saturated sodium bicarbonate solution and cooled to 15° C. The precipitated solid is filtered off, washed with 70 ml of toluene, then 70 ml of water and dried in an oven at 40° C. under vacuum. 213 g of 2-cyclohexylidene-2-cyanoacetamide are obtained.

1. customequipped with a mechanical stirrer
2. customthermometer and Dean-Stark trap connected to a condenser, under nitrogen
3. temperatureThe mixture is heated
4. temperatureunder reflux
5. customsimultaneously separating the water
6. distillationby distilling the water-toluene azeotrope
7. customThe separated water is collected in the Dean-Stark trap
8. customremoved at suitable time intervals
9. distillationon completion of the azeotropic distillation, it
10. washwashed with 400 ml of a saturated sodium bicarbonate solution
11. temperaturecooled to 15° C
12. filtrationThe precipitated solid is filtered off
13. washwashed with 70 ml of toluene
14. dry with material70 ml of water and dried in an oven at 40° C. under vacuum