反应详情

温度

50 °C

Hydrochloric acid (5 to 6 M in isopropanol, 4 mL) was added to a solution of tert-butyl (2S,3R)-3-hydroxy-4-phenylbutan-2-ylcarbamate (640 mg, 2.41 mmol) in ethyl acetate (4 mL). The mixture was stirred at 50° C. for 2.5 h and then concentrated. The solid was dissolved in warm ethanol (4-5 mL). Diethyl ether (ca 15 mL) was added under stirring to give the subtitle compound as a light lilic precipitate (290 mg, 60%).

1. concentrationconcentrated
2. dissolutionThe solid was dissolved in warm ethanol (4-5 mL)
3. additionDiethyl ether (ca 15 mL) was added
4. stirringunder stirring